DAFTAR PUSTAKA. 1. Baratawidjaya K G. Imunologi Dasar. Edisi ke 7. Jakarta : Balai Penerbit Fakultas Kedokteran Universitas Indonesia; 2006.

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1 DAFTAR PUSTAKA 1. Baratawidjaya K G. Imunologi Dasar. Edisi ke 7. Jakarta : Balai Penerbit Fakultas Kedokteran Universitas Indonesia; Abbas K A, Lichtmant A H, Pillai S. Cellular and Molecular Immunology. Sixth ed. Philadelphia : W B Saunders Company; Winarto W P. Mahkota dewa budi daya dan pemanfaatan untuk obat. Jakarta: Penebar Swadaya; Budijitno S. Peran Interferon Gamma, Perforin, Granzim Terhadap Apoptosis Sel Kanker Payudara Yang Mendapat Neoadjuvan Kemoterapi dan Ekstrak Phaleria macrocarpa [disertasi]. Semarang (Indonesia) : Fakultas Kedokteran Universitas Diponegoro; Ma at S. Imunomodulator manfaat dan bahayanya. Dalam Kusmita,L., dan Djatmika. Imunomodulator dan Perkembangannya. Prosiding Seminar Nasional Farmasi Tahun 2010 Cetakan ketiga. Semarang: Penerbit STIFAR Yayasan Farmasi 2010; p Sawitri E. Pengaruh Ekstrak Phylanthus niruri Linn Terhadap Kanker Kolon Tikus Sprague-Dawley yang Diinduksi 1,2 Dimethylhydranzine [disertasi]. Semarang (Indonesia) : Universitas Diponegoro; Bagian Patologi Klinik. Diktat Pegangan Kuliah Patologi Klinik I Jilid I. Semarang : Fakultas Kedokteran Universitas Diponegoro; Abbas K A, Lichtmant A H. Cellular and Molecular Immunologi. Fifth ed. Philadelphia : W B Saunders Company; Harmanto N. Mahkota dewa : obat pusaka para dewa. Jakarta : Agromedia Pustaka; Striawanti N. Mahkota Dewa (Phaleria macrocarpa) [Internet] [cited 2013 Feb 19]. Available from : Saifulhaq M. Pengaruh Pemberian Ekstrak Buah Mahkota Dewa Dosis Bertingkat terhadap Proliferasi Limfosit Lien pada Mencit Balb/C [Karya Tulis Ilmiah]. Semarang (Indonesia) : Fakultas Kedokteran Universitas Diponegoro;

2 Rohyami Y. Penentuan Kandungan Flavonoid dari Ekstrak Metanol Daging Buah Mahkota Dewa (Phaleria macrocarpa Scheff Boerl). LOGIKA [Internet] [cited 2013 Feb 15]; 5 : 1-8. Available from : Hendra R, Ahmad S, Oskoueian E, Sukari A and Shukor MY. Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit. BMC Complement Altern Med [Internet] [cited 2012 Nov 14]; 11:110. Available from : Pubmed. 14. Altaf R, Asmawi MZB, Dewa A, Sadikun A, and Umar MI. Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. Extracts. Pharmacogn Rev [Internet] [cited 2013 Aug 24]; 7(13): Available from : Pubmed 15. Widyastuti N, Widiyani T and Listyawati S. Efek Teratogenik Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Tikus Putih (Rattus norvegicus L.) Galur Wistar. Bioteknologi [Internet] [cited 2012 Nov 12];3(2): Available from : biosains.mipa.uns.ac.id/c/c0302/c pdf 16. Elliott Middleton JR, Chithan Kandaswami, Theoharides TC. The Effects of Plant Flavonoids on Mammalian Cells : Implications for Inflamation, Heart Disease and Cancer. Pharmacol Rev [Internet] [ cited 2012 Dec 1]; 52 : Available from : Jiao Y, Wen J, Yux. Influence of flavonoid of Astragalus membranaceu s stam and leaves on the function of cell mediated immunity in mice. Zhongguo Zhong Xi Yi Jie He Za Zhi [Internet] [ cited 2012 Dec 3] ;19(6): Available from : Pubmed. 18. Riwanto I, Budijitno S, Dharmana E, Handojo D, Prasetyo SA, Eko A, Suseno D and Prasetyo B. Effect of Phaleria Macrocarpa Supplementation on Apoptosis and Tumor Growth of C3H Mice With Breast Cancer Under Treatment With Adriamycin Cyclophosphamide. Int Surgery [Internet] [cited 2013 Jan 17]; 96(2): Available from : Pubmed. 19. Badan Pengawas Obat Makanan Republik Indonesia. Acuan Sediaan Herbal, Jakarta : Badan POM RI; Royal Museum for Central Africa. Prelude Medicinal Plant Database [Internet]. Tervure (Belgia) [cited 2013 Feb 19]. Available from : 965

3 Lestarini IA. Pengaruh Pemberian Phyllanthus niruri L Terhadap Respon Imunitas Seluler Mencit Balb/C yang diinfeksi dengan Salmonella thypimurium [tesis]. Semarang (Indonesia) : Universitas Diponegoro; Venkateswaran P S, Millman I, Blumberg BS. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: In vitro and in vivo studies. Proc. Nati. Acad. Sci. USA [Internet] [cited 2013 Jan 27]; 82 : Available from : Pubmed. 23. Nahid Tabassum, Sushma Chattervedi, S. S Aggrawal, Nissar Ahmed. Hepatoprotective studies on Paracetamol Induced Liver cell Damage in Albino Mice. JK-Practitioner [Internet] [cited 2013 Jan 2]; 12(4): Available from : Naik AD, Juvekar AR. Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian J Med Sci [Internet] [cited 2013 Jan 24] ; 57:387. Available from: Nworu CS, Akah PA, Okoye FB, Proksch P, Esimone CO. The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages. Immunol Invest [Internet] [cited 2012 Dec 21]; 39(4-5):550. Available from : Pubmed 26. World Health Organization. Research guidelines for evaluating the safety and efficacy of herbal medicine. Manila : World Health Organization Regional Office for the Western Pacific, 1993 : Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W. Current Protocols In Immunology Volume 2. California : John Wiley & Sons; Dahlan MS. Statistik Untuk Kedokteran dan Kesehatan. Edisi ke 5. Jakarta : Salemba Medika; Abbas K A, Lichtmant A H. Basic Immunology. Second ed. Philadelphia : Elsevier Saunders; Suhirman S, Winarti C. Prospek dan Fungsi Tanaman Obat Sebagai Imunomodulator. Buletin Perkembangan Teknologi Tanaman Rempah dan Obat XIX No.2 [Internet] [cited 2013 July 18]. Available from :

4 Yustisiana D. Pengaruh Pemberian Tolak Angin Anak Cair Terhadap Kadar Nitrit Oksida (NO) Pada Mencit Swiss [Karya Tulis Ilmiah]. Semarang (Indonesia) : Fakultas Kedokteran Universitas Diponegoro; Mills KHG. Regulatory T cells : friend or foe in immunity. Nat Rev Immunol [Internet] [cited July 20]; 4(11) : Available from : Hendra R, Ahmad S, Sukari A, Shukor MY, Oskoueian E. Flavonoid Analyses and Antimicrobial Activity of Various Parts of Phaleria macrocarpa (Scheff.) Boerl Fruit. International Journal of Molecular Sciences [Internet] [cited 2013 July 18]; 12(6): Available from: Pubmed 34. Hidalgo M, Shancez-Moreno C, de Pascual-Teresa S. Flavonoid-flavonoid Interaction and its effect on their antioxidant activity. Science-Direct [Internet] [cited 2013 July 18]; 171(1): Available from:

5 LAMPIRAN 53

9 57 HASIL OUTPUT SPSS 15.0 Descriptives Descriptive Statistics Perlakuan Limfoblas Valid N (listwise) N Minimum Maximum Mean Std. Skewness Kurtosis Statistic Statistic Statistic Statistic Deviation Statistic Statistic Std. Error Statistic Std. Error ,50 1,147,000,512-1,401,992 20,75 11,48 4,8200 2,93688,680,512 -,058, Frequencies N Mean Median Std. Dev iation Skewness Std. Error of Skewness Kurtosis Std. Error of Kurtosis Minimum Maximum Valid Missing Statistics Perlakuan Limfoblas ,50 4,8200 1,50 4,6800 1,147 2,93688,000,680,512,512-1,401 -,058,992,992 0, ,48 Explore Limfoblas Perlakuan K P1 P2 P3 Case Processing Summary Cases Valid Missing Total N Percent N Percent N Percent 5 100,0% 0,0% 5 100,0% 5 100,0% 0,0% 5 100,0% 5 100,0% 0,0% 5 100,0% 5 100,0% 0,0% 5 100,0% Descriptives Perlakuan Statistic Std. Error Limfoblas K Mean 1,7920, % Confidence Interval for Mean Lower Bound,6317 Upper Bound 2,9523 5% Trimmed Mean 1,7822

10 58 Median 2,0300 Variance,873 Std. Deviation,93446 Minimum,75 Maximum 3,01 Range 2,26 Interquartile Range 1,76 Skewness,095,913 Kurtosis -1,619 2,000 P1 Mean 6,7500 1, % Confidence Lower Bound 2,5284 Interval for Mean Upper Bound 10,9716 5% Trimmed Mean 6,7461 Median 7,3000 Variance 11,560 Std. Deviation 3,39998 Minimum 2,09 Maximum 11,48 Range 9,39 Interquartile Range 5,61 Skewness,034,913 Kurtosis 1,116 2,000 P2 Mean 6,4840 1, % Confidence Lower Bound 3,1472 Interval for Mean Upper Bound 9,8208 5% Trimmed Mean 6,4744 Median 6,5400 Variance 7,222 Std. Deviation 2,68736 Minimum 3,14 Maximum 10,00 Range 6,86 Interquartile Range 5,06 Skewness,091,913 Kurtosis -,992 2,000 P3 Mean 4,2540, % Confidence Lower Bound 2,8186 Interval for Mean Upper Bound 5,6894 5% Trimmed Mean 4,2822 Median 4,6200 Variance 1,336 Std. Deviation 1,15602 Minimum 2,50 Maximum 5,50

59 Range 3,00 Interquartile Range 2,04 Skewness -,887,913 Kurtosis,451 2,000 Tests of Normality Kolmogorov-Smirnov(a) Shapiro-Wilk Perlakuan Statistic df Sig.

11 59 Range 3,00 Interquartile Range 2,04 Skewness -,887,913 Kurtosis,451 2,000 Tests of Normality Kolmogorov-Smirnov(a) Shapiro-Wilk Perlakuan Statistic df Sig. Statistic df Sig. Limfoblas K,213 5,200(*),932 5,607 P1,230 5,200(*),965 5,843 P2,142 5,200(*),989 5,978 P3,224 5,200(*),949 5,729 * This is a lower bound of the true significance. a Lilliefors Significance Correction Boxplot

12 60 Oneway Limfoblas Test of Homogeneity of Variances Levene Statistic df1 df2 Sig. Limfoblas 1, ,187 ANOVA Sum of Squares df Mean Square F Sig. Between Groups 79, ,638 5,076,012 Within Groups 83, ,248 Total 163, Post Hoc Tests Dependent Variable: Limfoblas LSD Multiple Comparisons (I) Perlakuan K P1 P2 P3 (J) Perlakuan P1 P2 P3 K P2 P3 K P1 P3 K P1 P2 *. The mean diff erence is signif icant at the.05 lev el. Mean Diff erence 95% Confidence Interv al (I-J) Std. Error Sig. Lower Bound Upper Bound -4,95800* 1,44884,003-8,0294-1,8866-4,69200* 1,44884,005-7,7634-1,6206-2, ,44884,109-5,5334,6094 4,95800* 1,44884,003 1,8866 8,0294, ,44884,857-2,8054 3,3374 2, ,44884,104 -,5754 5,5674 4,69200* 1,44884,005 1,6206 7,7634 -, ,44884,857-3,3374 2,8054 2, ,44884,143 -,8414 5,3014 2, ,44884,109 -,6094 5,5334-2, ,44884,104-5,5674,5754-2, ,44884,143-5,3014,8414

13 FOTO KEGIATAN PENELITIAN 61

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15 63 BIODATA MAHASISWA Identitas Nama NIM : Josephine Rahma Gunawan : G2A Tempat/tanggal lahir : Semarang, 7 November 1991 Jenis Kelamin Alamat : Perempuan : Jl. Citandui VII / 144 Semarang Nomor Telepon : Nomor HP : josephine_rg@rocketmail.com Riwayat Pendidikan Formal 1. SD : SD Marsudirini Gedangan Lulus tahun : SMP : SMP PL Domenico Savio Lulus tahun : SMA : SMA Kolese Loyola Lulus tahun : FK UNDIP : Masuk tahun 2009 Keanggotaan Organisasi 1. Anggota Diklat BEM FK UNDIP 2010/ Sekretaris Medical Creative Art (MCA) 2010/ Bendahara PRMK FK UNDIP 2011/2012

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