LAMPIRAN 1 54
LAMPIRAN 2 HASIL PEMERIKSAAN Menerangkan bahwa mahasiswa/peneliti yang namanya di bawah ini: Peneliti : dr. Dwi Rita Anggraini, M.Kes. Nama Instansi : Departemen Anatomi Fak. Kedokteran USU Pada pemeriksaan karakterisasi simplisia/ekstrak Benalu Teh diperoleh hasil sebagai berikut: No. Pemeriksaan Hasil Rujukan Biaya (Rp) Metode 1 Alkaloid MMI 120.000 Reagen Meyer End. Putih (+) Reagen Dragendorff End. Coklat; lar. Kuning (+) Reagen Bouchardat End. Coklat; lar. Coklat (+) 2 Glikosida MMI 160.000 Reagen Fehling A + B Lar. Merah (+) Reagen Lieberman-Bouchard ungu (+) 3 Sianogenik : as. pikrat (-) MMI 45.000 4 Antrakinon : amonia (-) MMI 110.000 5 Tanin: FeCl 3 4,5% Hijau biru (+) MMI 20.000 6 Triterpen/Steroid: as. Asetat Hijau menjadi 35.000 anhidrat + as. Sulfat p ungu (+ triterpen) 7 Flavonoid MMI 105.000 Zn/HCl p kuning (+) Mg/HCl p Merah jingga (+) 8 Saponin : uji busa + HCl buih mantap (+) MMI 25.000 Ket. MMI (Materia Medika Indonesia) Jilid V 55
LAMPIRAN 3 Data baku penelitian Kelompok Waktu Intervensi BB awal BB akhir Berat massa Ki-67 labelling index K1- M1 3 mgg 0 152 174 1.37 1 K1-M2 3 mgg 0 150 183 3.09 3 K1-M3 3 mgg 0 157 168 0.76 1 K1-H1 3 mgg 0 169 188 0.1 1 K1-H2 3 mgg 0 143 147 0.42 1 P1-M1 3 mgg Benalu teh 1.5g/kgBB 148 153 0.22 1 P1-M2 3 mgg Benalu teh 1.5g/kgBB 147 145 0.55 3 P1-M3 3 mgg Benalu teh 1.5g/kgBB 128 186 0.09 0 P1-H1 3 mgg Benalu teh 1.5g/kgBB 156 176 0.38 1 P1-H2 3 mgg Benalu teh 1.5g/kgBB 161 179 0.34 0 K2-M1 6 mgg 0 137 155 0.68 1 K2-M2 6 mgg 0 139 152 0.26 0 K2-H1 6 mgg 0 151 164 0.37 3 K2-H2 6 mgg 0 116 134 0.29 1 K2-H3 6 mgg 0 172 180 0.32 1 P2-M1 6 mgg 3 mgg 0 3 mgg Benalu teh 1.5g/kgBB 143 196 0.31 1 P2-M2 6 mgg 3 mgg 0 3 mgg Benalu teh 1.5g/kgBB 174 161 0.21 1 P2-M3 6 mgg 3 mgg 0 3 mgg Benalu teh 1.5g/kgBB 146 167 0.64 0 P2-M4 6 mgg 3 mgg 0 3 mgg Benalu teh 1.5g/kgBB 145 160 0.26 0 P2-H3 6 mgg 3 mgg 0 3 mgg Benalu teh 1.5g/kgBB 164 204 0.37 1 P3-M1 6 mgg 3 mgg 0 3 mgg Benalu teh 3g/kgBB 145 158 0.32 0 P3-M2 6 mgg 3 mgg 0 3 mgg Benalu teh 3g/kgBB 125 139 0.15 0 P3-M3 6 mgg 3 mgg 0 3 mgg Benalu teh 3g/kgBB 180 206 0.24 1 P3-H1 6 mgg 3 mgg 0 3 mgg Benalu teh 3g/kgBB 156 175 0.14 1 P3-H3 6 mgg 3 mgg 0 3 mgg Benalu teh 3g/kgBB 131 168 0.16 0 Keterangan : 0 = tak ada 1 = lemah 2 = sedang 3 = kuat 56
LAMPIRAN 4 Explore Uji normalitas seluruh kelompok Descriptives Statistic Std. Error BM Mean 481.60 121.415 95% Confidence Interval for Mean Lower Bound 231.01 Upper Bound 732.19 5% Trimmed Mean 377.44 Median 320.00 Variance 3.685E5 Std. Deviation 607.074 Minimum 90 Maximum 3090 Range 3000 Interquartile Range 270 Skewness 3.675.464 Kurtosis 15.117.902 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. BM.300 25.000.542 25.000 a. Lilliefors Significance Correction kesimpulan : distribusi tidak normal 57
Explore UJi noormalitas 1 dan 2 BM Mean 732.00 287.707 95% Confidence Interval for Mean Lower Bound 81.16 Upper Bound 1382.84 5% Trimmed Mean 636.67 Median 400.00 Variance 8.278E5 Std. Deviation 909.808 Minimum 90 Maximum 3090 Range 3000 Interquartile Range 722 Skewness 2.320.687 Kurtosis 5.704 1.334 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. BM.288 10.019.699 10.001 a. Lilliefors Significance Correction kesimpulan : distribusi tidak normal 58
Explore Uji Normalitas kelompok 3, 4, dan 5 Descriptives Statistic Std. Error BM Mean 314.67 40.835 95% Confidence Interval for Mean Lower Bound 227.08 Upper Bound 402.25 5% Trimmed Mean 304.07 Median 290.00 Variance 2.501E4 Std. Deviation 158.153 Minimum 140 Maximum 680 Range 540 Interquartile Range 160 Skewness 1.420.580 Kurtosis 1.754 1.121 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. BM.230 15.032.835 15.011 a. Lilliefors Significance Correction kesimpulan: p value < alpha (Ho di tolak)distribusi tidak normal 59
Kruskal-Wallis Test Ranks Kelompok N Mean Rank BM 6 minggu tanpa intervensi 5 10.50 6mg,3mg benalu teh 1,5 5 9.20 6mg,3mg benalu teh 3gr 5 4.30 Total 15 Test Statistics a,b BM Chi-Square 5.374 df 2 Asymp. Sig..068 a. Kruskal Wallis Test b. Grouping Variable: Kelompok Explore UJi Normalitas kelompok 4 dan 5 Descriptives Statistic Std. Error BM Mean 280.00 46.904 95% Confidence Interval for Mean Lower Bound 173.90 Upper Bound 386.10 5% Trimmed Mean 267.78 Median 250.00 Variance 2.200E4 Std. Deviation 148.324 Minimum 140 Maximum 640 60
Range 500 Interquartile Range 175 Skewness 1.719.687 Kurtosis 3.673 1.334 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. BM.194 10.200 *.835 10.038 a. Lilliefors Significance Correction *. This is a lower bound of the true significance. Kesimpulan : p value > alpha (Ho di terima)distribusi normal T-Test Group Statistics Kelompok N Mean Std. Deviation Std. Error Mean BM 6mg,3mg benalu teh 1,5 6mg,3mg benalu teh 3gr 5 358.00 168.434 75.326 5 202.00 76.942 34.409 61
Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means F Sig. t df Sig. (2-tailed) Mean Difference Std. Error Difference 95% Confidence Interval of the Difference Lower Upper B M Equal variance s assumed Equal variance s not assumed 1.255.295 1.884 8.096 156.000 82.813-34.967 346.967 1.884 5.600.112 156.000 82.813-50.200 362.200 Hasil : pada alpha 5% didapat tidak ada perbedaan yang signifikan rata-rata berat masa tumor antara kelompok 4 dan kelompok 5 Uji normalitas berat badan Case Processing Summary Cases Valid Missing Total N Percent N Percent N Percent selisihbb 25 100.0% 0.0% 25 100.0% Descriptives Statistic Std. Error selisihbb Mean 19.3200 3.14151 95% Confidence Interval for Mean Lower Bound 12.8362 Upper Bound 25.8038 5% Trimmed Mean 18.9000 Median 18.0000 62
Variance 246.727 Std. Deviation 1.57075E1 Minimum -13.00 Maximum 58.00 Range 71.00 Interquartile Range 12.00 Skewness.705.464 Kurtosis 1.214.902 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. selisihbb.192 25.018.935 25.116 a. Lilliefors Significance Correction Case Processing Summary Cases Valid Missing Total N Percent N Percent N Percent selisihbb 15 100.0% 0.0% 15 100.0% Descriptives Statistic Std. Error selisihbb Mean 19.6667 3.94204 95% Confidence Interval for Mean Lower Bound 11.2118 Upper Bound 28.1215 5% Trimmed Mean 19.6296 Median 18.0000 Variance 233.095 Std. Deviation 1.52675E1 Minimum -13.00 63
Maximum 53.00 Range 66.00 Interquartile Range 13.00 Skewness.308.580 Kurtosis 1.615 1.121 Tests of Normality Kolmogorov-Smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig. selisihbb.199 15.115.915 15.163 a. Lilliefors Significance Correction kesimpulan : distribusi normal Oneway Notes Output Created 13-Aug-2012 05:33:29 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 Kelompok > 2 (FILTER) N of Rows in Working Data File 15 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each analysis are based on cases with no missing data for any variable in the analysis. 64
Syntax ONEWAY selisihbb BY Kelompok /STATISTICS DESCRIPTIVES /MISSING ANALYSIS /POSTHOC=BONFERRONI ALPHA(0.05). Resources Processor Time 00:00:00.078 [DataSet1] D:\dwi dkk\spss dwi.sav Elapsed Time 00:00:00.048 selisihbb Descriptives Std. 95% Confidence Interval for Mean N Mean Deviation Std. Error Lower Bound Upper 6 minggu tanpa intervensi 5 14.0000 4.18330 1.87083 8.8057 6mg,3mg benalu teh 1,5 5 23.2000 25.26262 11.29779-8.1677 6mg,3mg benalu teh 3gr 5 21.8000 9.93479 4.44297 9.4643 Total 15 19.6667 15.26746 3.94204 11.2118 ANOVA selisihbb Sum of Squares df Mean Square F Sig. Between Groups 245.733 2 122.867.489.625 Within Groups 3017.600 12 251.467 Total 3263.333 14 Post Hoc Tests Multiple Comparisons selisihbb Bonferroni Mean Difference (I- 95% Confidence Inte (I) Kelompok (J) Kelompok J) Std. Error Sig. Lower Bound Upper B 65
6 minggu tanpa intervensi 6mg,3mg benalu teh 1,5 6mg,3mg benalu teh 3gr -9.20000 10.02929 1.000-37.0761-7.80000 10.02929 1.000-35.6761 6mg,3mg benalu teh 1,5 6mg,3mg benalu teh 3gr 6 minggu tanpa intervensi 6mg,3mg benalu teh 3gr 6 minggu tanpa intervensi 6mg,3mg benalu teh 1,5 9.20000 10.02929 1.000-18.6761 1.40000 10.02929 1.000-26.4761 7.80000 10.02929 1.000-20.0761-1.40000 10.02929 1.000-29.2761 kesimpulan : tidak ada perbedaan rata2 antar kelompok Uji Ki-67 NPar Tests Notes Output Created 10-Sep-2012 09:52:10 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset DataSet1 Filter Weight Split File N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. 66
Syntax NPAR TESTS /M-W= Ki67baru BY Kelompok(4 5) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.141 Elapsed Time 00:00:00.125 Number of Cases Allowed 112347 a. Based on availability of workspace memory. Mann-Whitney Test Ranks Kelompok N Mean Rank Sum of Ranks Ki67baru 6mg,3mg benalu teh 1,5 5 6.00 30.00 6mg,3mg benalu teh 3gr 5 5.00 25.00 Total 10 Test Statistics b Ki67baru Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.600 Asymp. Sig. (2-tailed).549 Exact Sig. [2*(1-tailed Sig.)].690 a a. Not corrected for ties. b. Grouping Variable: Kelompok 67
NPar Tests Notes Output Created 10-Sep-2012 09:51:48 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. Syntax NPAR TESTS /M-W= Ki67baru BY Kelompok(3 5) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.047 Elapsed Time 00:00:00.031 Number of Cases Allowed 112347 a. Based on availability of workspace memory. Mann-Whitney Test Ranks Kelompok N Mean Rank Sum of Ranks Ki67baru 6 minggu tanpa intervensi 5 6.70 33.50 6mg,3mg benalu teh 3gr 5 4.30 21.50 Total 10 68
Test Statistics b Ki67baru Mann-Whitney U 6.500 Wilcoxon W 21.500 Z -1.386 Asymp. Sig. (2-tailed).166 Exact Sig. [2*(1-tailed Sig.)].222 a a. Not corrected for ties. b. Grouping Variable: Kelompok NPar Tests Notes Output Created 10-Sep-2012 09:51:28 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. Syntax NPAR TESTS /M-W= Ki67baru BY Kelompok(3 4) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.062 Elapsed Time 00:00:00.031 Number of Cases Allowed 112347 a. Based on availability of workspace memory. [DataSet1] D:\dwi dkk\spss dwi.sav 69
Mann-Whitney Test Ranks Kelompok N Mean Rank Sum of Ranks Ki67baru 6 minggu tanpa intervensi 5 6.30 31.50 6mg,3mg benalu teh 1,5 5 4.70 23.50 Total 10 Test Statistics b Ki67baru Mann-Whitney U 8.500 Wilcoxon W 23.500 Z -.956 Asymp. Sig. (2-tailed).339 Exact Sig. [2*(1-tailed Sig.)].421 a a. Not corrected for ties. b. Grouping Variable: Kelompok NPar Tests Notes Output Created 10-Sep-2012 09:50:57 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. 70
Syntax NPAR TESTS /M-W= Ki67baru BY Kelompok(1 2) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.031 Elapsed Time 00:00:00.015 Number of Cases Allowed 112347 a. Based on availability of workspace memory. Mann-Whitney Test Ranks Kelompok N Mean Rank Sum of Ranks Ki67baru 3 minggu tanpa intervensi 5 6.30 31.50 3 minggu benalu teh 1,5g 5 4.70 23.50 Total 10 Test Statistics b Ki67baru Mann-Whitney U 8.500 Wilcoxon W 23.500 Z -.949 Asymp. Sig. (2-tailed).343 Exact Sig. [2*(1-tailed Sig.)].421 a a. Not corrected for ties. b. Grouping Variable: Kelompok NPar Tests Notes Output Created 10-Sep-2012 09:50:27 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 71
N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. Syntax NPAR TESTS /K-W=Ki67baru BY Kelompok(3 5) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.047 Elapsed Time 00:00:00.032 Number of Cases Allowed 112347 a. Based on availability of workspace memory. Kruskal-Wallis Test Ranks Kelompok N Mean Rank Ki67baru 6 minggu tanpa intervensi 5 10.00 6mg,3mg benalu teh 1,5 5 7.70 6mg,3mg benalu teh 3gr 5 6.30 Total 15 Test Statistics a,b Ki67baru Chi-Square 2.216 df 2 Asymp. Sig..330 a. Kruskal Wallis Test b. Grouping Variable: Kelompok 72
NPar Tests Notes Output Created 10-Sep-2012 09:50:00 Comments Input Data D:\dwi dkk\spss dwi.sav Active Dataset Filter Weight Split File DataSet1 N of Rows in Working Data File 25 Missing Value Handling Definition of Missing User-defined missing values are treated as missing. Cases Used Statistics for each test are based on all cases with valid data for the variable(s) used in that test. Syntax NPAR TESTS /K-W=Ki67baru BY Kelompok(1 5) /MISSING ANALYSIS. Resources Processor Time a 00:00:00.031 Elapsed Time 00:00:00.015 Number of Cases Allowed 112347 a. Based on availability of workspace memory. 73
Kruskal-Wallis Test Ranks Kelompok N Mean Rank Ki67baru 3 minggu tanpa intervensi 5 17.20 3 minggu benalu teh 1,5g 5 12.80 6 minggu tanpa intervensi 5 15.00 6mg,3mg benalu teh 1,5 5 11.10 6mg,3mg benalu teh 3gr 5 8.90 Total 25 Test Statistics a,b Ki67baru Chi-Square 4.912 df 4 Asymp. Sig..296 a. Kruskal Wallis Test b. Grouping Variable: Kelompok 74