S, penyunting. Buku Ajar Neurologi Anak. Edisi ke 1. Jakarta : BP IDAI. epilepsi. Semarang : Penerbit UNDIP ; p

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1 DAFTAR PUSTAKA 1. Soetomenggolo TS. Kejang demam. Dalam : Soetomenggolo TS, Ismael S, penyunting. Buku Ajar Neurologi Anak. Edisi ke 1. Jakarta : BP IDAI ; p Pusponegoro HD. Kejang demam patofisiologi dan penatalaksanaannya. Dalam: Kustiowati E, ed. Kumpulan makalah pertemuan nasional I epilepsi. Semarang : Penerbit UNDIP ; p Dadiyanto Dwi W, dkk. Buku Ajar Ilmu Kesehatan Anak. Semarang ; Badan Penerbit Universitas Diponegoro; Jonhston MV. Seizure in childhood and prevalence of febrile seizure. In : Behrman RE, Kliegman RM, Jenson HB, ed. Nelson Textbook of Pediatrics. 18th ed. Philadelphia : WB Saunders Co;2007.p Bessisso MS, Elsaid MF, Almula NA, Kadomi NK, Zeidan SH, Azzam SB, dkk. Recurrence risk after a first febrile convulsion. Saudi Med J 2001;22: Kjeldsen MJ, Corey LA, Solaas MH. Genetic factors in seizures: a population based study of US, Norwegian and Danish twin pairs. Twin res hum genet 2005; Abolfazl Mahyar, Parviz Ayazi, Mazdak Fallahi, and Amir Javadi. Risk Factors of the First Febrile Seizures in Iranian Children. Hindawi Publishing Corporation International Journal of Pediatrics 2010; 1115;

2 8. Parmar RC, Sahu DR. Bavdekar SB. Knowledge attitude and practices of parents of children with febrile convulsion. J postgrad Med 2001;47: Pisacane A, Sansone R, Impagliazzo N, Cappolo A, Rolando P, Tregrossi C, et al. Iron deficiency anemia and febrile convulsion. BMJ 1996 ; 12 : Kobrinsky NL, Yager JY, Cheang MS, Randall WY, Terenbein M. Does iron deficiency raise the seizure threshold?. J Child Neurol 1995 ; 10 : Dirjen Kesmas RI. Situasi gizi terkini dan penanggulangan masalah gizi di Indonesia. Departemen Kesehatan RI, 2000 Juli 13. Michael J. Gibney,dkk. Gizi Kesehatan Masyarakat. Jakarta. EGC : Fuadi, Tjipta Bahtea, Noor W. Faktor Resiko Bangkitan Kejang Demam Pada Anak. Sari Pediatri. 2010;12(3): Kenneit F Swaiman, Stephen Ashwal, Donna M. Ferriero. Pediatric Neuroloy Principles and Practice. Ed 4th. Phyladelphia. MOSBY : Fisher RS, Wu J. Basic electrophysio logy of febrile seizures. In: Baram TZ, Shinnar S, ed., Febrile Seizures. San Diego : Academic press;2002.p

3 17. Tath Z, Yan XX, Hafteglou S, Ribak CE, Baram TZ. Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J Neurosci 1998;18: Wu J, Fisher RS. Hyperthermic Spreading Depressions in the immature Rat Hippocampal Slice. J Neurophysiol 2000; 84(3): Jensen F E. Sanchez R M. Why Does the Developing Brain Demonstrate Heightened Susceptibility to Febrile and Other Provoked Seizures?. In: Baram T Z, Shinnar S. ed. Febrile Seizures. San Diego: Academic Press;2002.p Berg AT. Recurrent Febrile Seizures. In: Baram FZ, Sinnar S.ed. Febrile Seizures. San Diego: Academic Press;2002.p Menkes JH, Sankar R. Paroxysmal Disorders. Dalam:.Menkes JH, Sarnat BH, penyunting. Child neurology. Edisi ke-6. Philadelphia: Lippincott Williams & Wilkins JR; 2000.h Hauser WA, Anneger JE, Anderson E, Kurland LT. The risk of seizures disorders among relatives of children with ferible convulsions. Neurology 1985;35: Beard J. Iron deficiency alters brain development and functioning. J Nutr 2003 ; 133: Mittal RD, Pandey A, Agarwal KN. Effect of latent iron deficiency on GABA and glutamate neuroreceptors in rat brain. Indian J Clin Biochem 2002; 17 (2) :

4 25. Guyton and Hall. Buku Ajar Fisiologi Kedokteran, edisi 11. Jakarta. EGC : Nathan DG, Orkin SH, Oski FA, Ginsburg D. Nathan and Oski s Hematology of Infancy and Childhood. 7th ed. Philadelphia: Saunders; Bambang P H, Sutaryo, Ugrasena I, Windiastutui E, Abdulsalam M. Buku Ajar Hematologi Onkologi Anak. Ikatan Kedokteran Anak Indonesia; P Corwin. Buku Saku Patofisiologi. Jakarta : EGC; Jafar Nurhaedar, Peranan gizi pada anemia ibu hamil. Makassar. Universitas Hasanudin : Wiwik dan Andi Sulistyo. Buku Ajar Asuhan Keperawatan Pada Klien Dengan Gangguan Sistem Hematologi. Jakarta : Salemba Medika; S. Wheby M. Anemia: classification, mechanism, diagnosis, and physiologic effects. Fundamentals of clinical hematology. 5 th ed. W. B. Saunders Company; P Badham J, Zimmermann MB, Kraemer K. The Guidebook Nutritional Anemia. SIGHT AND LIFE; P Wahyuni A S, Anemia Defisiensi Besi Pada Balita. Fakultas Kedokteran USU ; Kharunnisa I, Syarief I, Rahmatini. Gambaran Elektrolit dan Gula Darah Pasien Kejang Demam yang Dirawat di Bangsal Anak RSUP Dr. M. Djamil. Jurnal Kesehatan Andalas :

5 35. Sumijati M.E, dkk. Asuhan Keperawatan Pada Kasus Penyakit Yang Lazim Terjadi Pada Anak. Surabaya. PERKANI : Abdul Khanis. Defisiensi Besi dengan Parameter stfr sebagai Faktor Risiko Bangkitan Kejang Demam. Semarang. Ilmu Kesehatan Anak Universitas Diponegoro : Attila D, dkk. Kejang Demam dan Faktor yang Mempengaruhi Rekurensi. Jakarta. Sari Pediatri : 2012;14(1): Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor or the first febrile seizure. Epilepsia 2002; 43: Kumari P, Nair MK, Nair SM, Kailas L, Geeta S. Iron deficiency as a risk factor for simple febrile seizure--a case control study. Indian Pediatrics 2012; 49: Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, et al. The association between iron deficiency and febrile seizures in childhood. Clin Pediatr (Phila) 2009; 48:

6 No Usia (bulan) Jenis Kelamin Riwayat Keluarga Durasi kejang Frekuensi Kejang Kelompok Status Hb 1 47 P Kasus N 2 14 L Kasus N 3 6 L Kasus N 4 6 L Kasus N 5 9 L Kasus N 6 29 L Kasus N 7 48 P Kasus N 8 9 P Kasus N 9 21 L Kasus N L Kasus N L Kasus anemia 12 2 L Kasus N 13 5 P Kasus N 14 9 P Kasus N L Kasus anemia

7 16 18 P Kasus anemia L Kasus anemia L Kasus anemia L Kasus anemia 20 3 P Kasus anemia P Kasus anemia P Kasus anemia L Kasus anemia L Kasus anemia P Kasus anemia P Kasus anemia 27 7 P Kasus anemia L Kasus anemia L Kasus anemia 30 9 L Kasus N P Kasus anemia 32 2 L Kasus anemia

8 33 8 L Kasus N L Kasus N L Kasus N P Kasus anemia P Kasus N L Kasus N L Kasus anemia L Kasus N L Kasus anemia L Kasus N L Kasus anemia L Kasus anemia L Kasus N L Kasus anemia 47 6 P Kasus N L Kontrol N L Kontrol N

9 50 13 P Kontrol N L Kontrol N L Kontrol N L Kontrol N L Kontrol N L Kontrol N L Kontrol N L Kontrol N L Kontrol N 59 7 L Kontrol N P Kontrol anemia 61 6 L Kontrol N L Kontrol N L Kontrol N P Kontrol N L Kontrol N L Kontrol N

10 67 5 L Kontrol N L Kontrol N P Kontrol N 70 7 P Kontrol N P Kontrol N 72 8 P Kontrol N 73 8 L Kontrol N L Kontrol N 75 1 P Kontrol N 76 9 L Kontrol N L Kontrol N P Kontrol N 79 2 P Kontrol N L Kontrol N L Kontrol anemia L Kontrol anemia 83 8 L Kontrol anemia

11 84 18 P Kontrol anemia L Kontrol anemia L Kontrol anemia L Kontrol anemia L Kontrol anemia P Kontrol N 90 2 P Kontrol N L Kontrol N L Kontrol N L Kontrol anemia P Kontrol N

12 Hasil Analisis Data 1. Lampiran karakteristik dasar subyek penelitian Jenis kelamin Kelompok * Jenis Kelamin Crosstabulation Jenis Kelamin L P Total Kelompok Kasus Count Expected Count 32,0 15,0 47,0 % within Kelompok 66,0% 34,0% 100,0% % within Jenis Kelamin 48,4% 53,3% 50,0% % of Total 33,0% 17,0% 50,0% Kontrol Count Expected Count 32,0 15,0 47,0 % within Kelompok 70,2% 29,8% 100,0% % within Jenis Kelamin 51,6% 46,7% 50,0% % of Total 35,1% 14,9% 50,0% Total Count Expected Count 64,0 30,0 94,0 % within Kelompok 68,1% 31,9% 100,0% % within Jenis Kelamin 100,0% 100,0% 100,0% % of Total 68,1% 31,9% 100,0% Chi-Square Tests Asymp. Sig. (2- Exact Sig. (2- Exact Sig. (1- Value df Pearson Chi-Square,196 a 1,658 Continuity Correction b,049 1,825 Likelihood Ratio,196 1,658 Fisher's Exact Test,825,413 N of Valid Cases 94

13 a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 15,00. b. Computed only for a 2x2 table Usia Test Statistics a Usia Mann-Whitney U 923,000 Wilcoxon W 2051,000 Z -1,374 Asymp. Sig. (2-tailed),170 a. Grouping Variable: Kelompok Riwayat keluarga Kelompok * Riwayat Keluarga Crosstabulation Riwayat Keluarga - + Total Kelompok Kasus Count Expected Count 26,5 20,5 47,0 % within Kelompok 57,4% 42,6% 100,0% % within Riwayat Keluarga 50,9% 48,8% 50,0% % of Total 28,7% 21,3% 50,0% Kontrol Count Expected Count 26,5 20,5 47,0 % within Kelompok 55,3% 44,7% 100,0% % within Riwayat Keluarga 49,1% 51,2% 50,0% % of Total 27,7% 22,3% 50,0% Total Count Expected Count 53,0 41,0 94,0 % within Kelompok 56,4% 43,6% 100,0% % within Riwayat Keluarga 100,0% 100,0% 100,0% % of Total 56,4% 43,6% 100,0%

14 Chi-Square Tests Asymp. Sig. (2- Exact Sig. (2- Exact Sig. (1- Value df Pearson Chi-Square,043 a 1,835 Continuity Correction b, ,000 Likelihood Ratio,043 1,835 Fisher's Exact Test 1,000,500 N of Valid Cases 94 a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 20,50. b. Computed only for a 2x2 table 2. Analisis anemia dengan manifestasi klinis kejang demam Kelompok * Status Hb Crosstabulation Status Hb anemia N Total Kelompok 1 Count Expected Count 17,0 30,0 47,0 % within Kelompok 51,1% 48,9% 100,0% % within Status Hb 70,6% 38,3% 50,0% % of Total 25,5% 24,5% 50,0% 2 Count Expected Count 17,0 30,0 47,0 % within Kelompok 21,3% 78,7% 100,0% % within Status Hb 29,4% 61,7% 50,0% % of Total 10,6% 39,4% 50,0% Total Count Expected Count 34,0 60,0 94,0 % within Kelompok 36,2% 63,8% 100,0%

15 % within Status Hb 100,0% 100,0% 100,0% % of Total 36,2% 63,8% 100,0% Chi-Square Tests Asymp. Sig. (2- Exact Sig. (2- Exact Sig. (1- Value df Pearson Chi-Square 9,031 a 1,003 Continuity Correction b 7,787 1,005 Likelihood Ratio 9,237 1,002 Fisher's Exact Test,005,002 N of Valid Cases 94 a. 0 cells (0,0%) have expected count less than 5. The minimum expected count is 17,00. b. Computed only for a 2x2 table Durasi kejang Status Hb * Durasi Kejang Crosstabulation Durasi Kejang < 15 menit > 15 menit Total Status Hb anemia Count Expected Count 31,5 2,5 34,0 % within Status Hb 91,2% 8,8% 100,0% % within Durasi Kejang 35,6% 42,9% 36,2% % of Total 33,0% 3,2% 36,2% N Count Expected Count 55,5 4,5 60,0 % within Status Hb 93,3% 6,7% 100,0% % within Durasi Kejang 64,4% 57,1% 63,8% % of Total 59,6% 4,3% 63,8% Total Count

16 Expected Count 87,0 7,0 94,0 % within Status Hb 92,6% 7,4% 100,0% % within Durasi Kejang 100,0% 100,0% 100,0% % of Total 92,6% 7,4% 100,0% Chi-Square Tests Asymp. Sig. (2- Exact Sig. (2- Exact Sig. (1- Value df Pearson Chi-Square,146 a 1,702 Continuity Correction b, ,000 Likelihood Ratio,143 1,705 Fisher's Exact Test,701,497 N of Valid Cases 94 a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 2,53. b. Computed only for a 2x2 table Frekuensi kejang Frekuensi kejang * Status Hb Crosstabulation anemia Status Hb N Total Frekuensi kejang 1,00 Count Expected Count 17,4 30,6 48,0 % within Frekuensi kejang 20,8% 79,2% 100,0% % within Status Hb 29,4% 63,3% 51,1% % of Total 10,6% 40,4% 51,1% 2,00 Count Expected Count 16,6 29,4 46,0 % within Frekuensi kejang 52,2% 47,8% 100,0% % within Status Hb 70,6% 36,7% 48,9% % of Total 25,5% 23,4% 48,9%

17 Total Count Expected Count 34,0 60,0 94,0 % within Frekuensi kejang 36,2% 63,8% 100,0% % within Status Hb 100,0% 100,0% 100,0% % of Total 36,2% 63,8% 100,0% 1 = 1 x kejang dalam 24 jam 2 = 2 x kejang dalam 24 jam Chi-Square Tests Asymp. Sig. (2- Exact Sig. (2- Exact Sig. (1- Value df Pearson Chi-Square 9,993 a 1,002 Continuity Correction b 8,682 1,003 Likelihood Ratio 10,216 1,001 Fisher's Exact Test,002,001 N of Valid Cases 94 a. 0 cells (0,0%) have expected count less than 5. The minimum expected count is 16,64. b. Computed only for a 2x2 table

18 RIWAYAT HIDUP PENULIS A. Identitas Nama : Muhamad Helmi H Tempat, tanggal lahir : Salatiga 15 September 1992 Agama Jenis Kelamin Alamat : Islam : Laki-laki : Jalan Raden Patah 145 Salatiga B. Riwayat Pendidikan 1. TK Tarbiyatul Banin Salatiga 2. SD Negeri 01 Salatiga 3. SMP Negeri 01 Salatiga 4. SMA Negeri 01 Salatiga C. Keterangan Keluarga Ayah Kandung Ibu Kandung Kakak Kandung Adik Kandung : Drs Fadholi : Dra Anis Rosiqoh : Happy Risdian : Muhammad Henri Indrawan

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