Artikel Asli KORELASI ANTARA RESPONS PIGMENTASI AKIBAT PAJANAN MATAHARI DENGAN DERAJAT PARUT AKNE VULGARIS Istiana Fiatiningsih, Kristiana Etnawati, Agnes Sri Siswati Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin FK Universitas Gadjah Mada/RSUP dr. Sardjito Yogyakarta ABSTRAK peningkatan produksi matriks metaloproteinase yang mendegradasi kolagen sehingga terjadi pigmentasi kulit. dan hitung morfologi parut. parut akne. Kata kunci: Pajanan sinar matahari, respons pigmentasi, parut akne, parut makula Koresponsdensi : ABSTRACT increases production of matrix metalloproteinase that degrade extracellular matrix collagen causing of atrophic scar formation. Sunlight exposure cause melanogenesis resulting in skin pigmentation. without using cosmetic products containing whitening, sunscreen and acne medication in the last count were measured. severity. Keywords: Sunlight exposure, skin pigmentation, acne scars, macular scars 51
PENDAHULUAN 1 2 dapat 4 5 Pasien akne 6,7 8 Pajanan matahari 10 14 reactive oxygen species 15 Oksidasi mediator inflamasi dan kemoatraktan sel proinflamasi 16,17 pada kulit manusia secara in vivo 18 Penelitian BAHAN DAN CARA 20 sampel dilakukan secara consecutive sampling Chromameter terpajan matahari (dahi) dan area non-pajanan matahari Scarring Classification 21 lesi meliputi: lesi 1-10 (nilai 1), lesi 11-20 (nilai 2), dan lesi 21 p p<0,05 dan HASIL PENELITIAN Karakteristik subjek Penelitian ini dilakukan di Poliklinik Ilmu Kesehatan 52
I Fiatiningsih, dkk. derajat parut akne vulgaris Lima pasien tidak dapat diikutkan dalam analisis karena Tabel 1. inklusi dan eksklusi di Poliklinik Ilmu Kesehatan Kulit dan Subjek Laki-laki Perempuan Derajat keparahan akne Derajat parut akne Makula eritematosa Boxcar Rolling scars Delta L* Delta a* Jumlah (Persentase 20 (17-27) 64 (84,21) 62 (81,58) jenis kelamin (p=0,001) dan derajat keparahan akne Berdasarkan analisis post hoc Gambar 1. Classification Spearman) Berdasarkan uji korelasi Spearman, didapatkan parut atrofi ( ) tetapi tidak Tabel 2. Variabel Nilai delta L* Nilai delta L*a*b Hitung morfologi parut akne ME MHiper MHipo Ice-pick Boxcar Rolling p=0,674 p=0,547 r=0,070 p=0,452 r=0,087 r=-0,012 p=0,128 r=0,176 r=0,150 p=0,004** p=0,001** p=0,001** r=-0,226 p=0,082 r=0,201 ME:Mhiper: Mhipo: makula
DISKUSI Parut akne pada penelitian ini didapatkan pada 4 India pada 76,4% kasus akne, 5 22 Parut akne pada penelitian ini dijumpai 57% dan laki-laki 48%, di India dijumpai parut akne 5 dan 24 5 25 Pada penelitian dijumpai rolling scars 26 25 Parut akne dapat terjadi karena kerusakan struktur 10 28 karena Makula eritema terjadi karena dilatasi 21 Pada 54
I Fiatiningsih, dkk. derajat parut akne vulgaris KESIMPULAN, dan rolling scars) DAFTAR PUSTAKA Photodynamic therapy in the management of acne: An update Postacne scarring: A review of its pathophysiology and treatment Practical evaluation and management of atrophic acne scars A clinical evaluation of acne scarring and its incidence. different from adolescent acne? Treatment of acne scarring Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, Continental Indian, and African American women. Inflammation in acne scarring: A comparison of the responses in lesions from patients prone and not prone to scar. Multimodal treatment of acne, acne scars, and pigmentation human skin Pigmentation effect of solar simulated radiation as compared with UVA and UVB radiation. Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. Human skin responses to UV radiation: pigment in the facilitates apoptosis. of different wave. UV and pigmentation: Molecular mechanisms and social controversies New to Improve Outcomes in Acne Group. S50 metalloproteinases in photoaging. 20-4 A comparison of current acne grading systems and proposal of a novel system. 416-418 grading system. An epidemiological study of acne in female adults: Results of a survey conducted in France. epidemiological study of acne vulgaris in Hong Kong adolescents. Prevalence of facial acne in adults. J Scarring and none South India measurements of skin pigmentation in situ 618-26 Acne scars: Pathogenesis, scars: A review with clinical and ultrasound correlation. Acne scars: Classification 55