Nkh Al Efk Pm Ekk El Ak Klm (Tlum gul Wll) h Smg Tku Puh Yu Au Nugh1, L Rhyu2, R Ih Su2 1 Pu Bm Tklg D Kh B Lgk Kmk RI 2 Fkul Fm. Uv Pcl. Jk ml: u_1955@yh.cm Ac I I fly ll lm f m cul, cu 10-15% f m cul uff fm fly. Ifly c cu y h hu wf, u ly 40-60% cu y h hu. D fly ly f cm, whch m wy m h lvl f ml fly. Cm ccumc h c cu fly, mg h, h l h um f mz, m mly lw, h vlcy f mz. Klm (Tlum gul Wll) c c h um mly f mz c lvl. Th uy m m h ffc f klm xc mg f ml W. Th ffc f klm xc mg ug h WHO (2000) wh ml wh mu. 225 f hl xc; 675 2025 mg / kg. m lly f 45 y. Dll w cl cmv g K Gg 225 mg / kg. Th ul f h uy, klm xc 225; 675 2025 mg / kg BB gv f 45 y l ucv g ym c ll c h um f A mg, chy g my mcy h m f mfu. Kyw : Klm, Tlum gul Wll, Smg, Al R Phulu D I fl mh muk mlh g g um, k 10-15% g yg uh mkh m fl. Ifl k lh hk um muu, kyy 40 60% k lh hk um. D fl k l m yg muk lh u c yg g uuk mghu gk kuu. K m yg myk fl l jumlh mz yg kug, ml mz yg h, kc gk mz gy.1 Klm (Tlum gul Wll) muk lh u m yg kl lh myk I g ku lm cmu mum.2 B l myuk hw kk klm m k uj k ku g l 45,1(36,655,78) mg/10 g () mc.3 Ekk k Klm 5; 25 50 mg/200 g mgkk jumlh, ml mz mgkk k hm.4 Tuju l lh uuk mghu fk m kk k Klm h mg ku uh j glu W. 35 35
M M Bh Pl Ak Klm lm uk jg kg gk Ak Gg K lm uk k kg yg mh uuh. Hw Pc Hw c yg guk lh ku uh glu W, j klm j, 160 200 gm yg lh Lum Hw C Pulg Bm Fm B Lgk. Dk. RI. Jk. M Pl5 P h uj Bh yg uh kg, glg kk g c m mgguk l 70% kmu fl uk lm v vcuum g uhu 500C hgg uk kk kl. Ekk kl Klm yg m lm l uu ljuy guk g h l. P hw c Slum mlkuk c, ku lh yg h k cc kmu lm u mggu. Tku klmkk mj 5 klmk c ck mg-mg klmk 5 k. Plk l Pm h uj lm g gk yg k c l lm 45 h mu klmk hw c yg mlu: Klmk I :Nml (kl gf); Klmk II : Ekk Klm 225 mg/kg.; Klmk III : Ekk Klm 675 mg/kg. Klmk IV : Ekk Klm 2025 mg/kg. Klmk V : Ekk Gg K (kl f) 225 mg/kg. Mg-mg klmk h uj lm 45 h. P kh m h, ku, lkuk mh gml g m lkuk mk: mg m yg lumy uh cuc g NCL flg 0,9%; mu hlg g ; ghug jumlh mg A B, m m h k guku m uulu mfu. Hl Pmh Pmg u mggu kl lm l. Hl uj k m kk Klm mmh u g kk Klm. Hl mg lh Gm 1. B muk lh u k kh hw uj. Hl mg lm l klmk yg k lku kkk y kug 10 gm, gk lku mujukk kkk g gfk. Hl mujukk hw m Klm muu Gg K mgkk yg lm l hw c lm k h.6 Hl uj l v, klmk ml, klmk lku (kk Klm 225; 675 2025 mg/kg.) klmk Gg K 225 mg/kg k mk (>0,05) (Gm 2). Hl mujukk hw kk Klm lum mmu mgkk mku lku yg k mk gg. T uk lgkug-lgkug uulu m fu. El uulu mfu u j l yu l l 36 Jul Kfm I. Vl 2.1.2012 : 35-42 36 Jul Kfm I. vl 1.1.2012 : 35-42
Efk Pm Ekk...(Yu Au Nugh,.l) l-l mg. Sl l fug uuk mghlk z mk yg luk uuk lf, f mmlh l-l mg. Sl l muk g FSH lm uulu mfu m FSH mmguh kmg wl mg. LH mmguh l lyg uuk mmuk, FSH luk lm mg.7,8,9 Dg mk c k lgug huug g kj FSH, LH. 70 60 59.4 60 50 B 40 43.75 39.5 37.2 34.2 30 20 29.5 25.62 23.37 21.37 24.75 ( 17.12 g ) 13.2 12.5 10 5.75 0 0 Mggu k- Mggu k- Mggu k- Mggu k0 2 4 6 Aku Klm 225mg/kg Klm 675mg/kg Klm 2025mg/kg Gm 1. R kk ku uh lm l 37
R / 0.012 0.0116 0.0115 0.0108 0.011 0.0105 0.01 0.0109 0.0102 0.01 0.0095 0.009 Gm 2. R ku uh lh m h uj. 0.00385 R m / 0.0038 0.0038 0.00375 0.0037 0.0037 0.0037 0.0037 0.00365 0.0036 0.0036 0.00355 0.0035 Gm 3. R m ku uh lh m h uj. 38 Jul Kfm I. Vl 2.1.2012 : 35-42
Efk Pm Ekk...(Yu Au Nugh,.l) Hl uj l v, m klmk ml, klmk lku (kk Klm 225; 675 2025 mg/kg.) klmk Gg K 225 mg/kg k mk (>0,05) (Gm 3). P mg mz uk lh fug m, lm m yg hlk lh l lyg uh mj 5- -h (DHT) yg mmu mg mz m.10 Al DHT mgk mk m k fug g k. Hl uj l v, gk jumlh l mg A klmk ml, klmk lku (kk Klm 225; 675 2025 mg/kg.) klmk Gg K 225 mg/kg mk (<0,05) (Gm 4). Pgk jumlh l mg A kmugk y z lm k Klm yg mgg kk FSH. FSH mmguh l l uuk mgg gk g hgg mgkk ul hm g l h yg g kmg.11 Ekk Klm 225 mg/kg mmuy kh g kk Gg K 225 mg.kg lm mmguh kc gk l mg A. Hl uj k m kk Klm 225;675 2025 mg/k. Th jumlh mg B (Gm 5) k klmk. Hl u kmugk k l mg B hy um IV; V VI lm klu l mfu hgg gk jumlh l-l mg B k k. Hl uj k h jumlh m m h k mujukk mk klmk ml g klmk lku (kk Klm 225; 675 2025 mg/kg.) klmk Gg K 225 mg/kg (<0,05) (Gm 6). Klm mgkk hm, m hm lm mlh m m m.11 4.5 R j u m l h m g A 4.16 4 3.36 3.5 3 2.5 2.71 2.81 2.26 2 1.5 1 0.5 0 Gm 4. R jumlh mg A h uj ku uh lh m 39
S m g 1.97 2 1.8 1.77 1.84 1.79 1.84 1.6 1.4 B 1.2 1 j 40 u Jul Kfm I. Vl 2.1.2012 : 35-42
Efk Pm Ekk...(Yu Au Nugh,.l) 41
1. Sg, N. Ifl P P. Mjlh Ilmh UPN V. 1999.10(2); 59-62. 2. Whyu, S., Hy. Kkk Tlum culum G Tlum gul Wll. W Tumuh O I. 1999.5(4);5-6 3. Nugh YA, Ww L, Puju, Nu B. Tk ku kh kk m jw ( Tlum culum G). Jul Fm Pcl. 2002. 1(1): 57-64. 4. Nugh, YA., S O.,H. Kh Km Tlum culum G Tlum gul Wll. Pulg Fm. B Lgk. Dm Kh RI, 2000.1-9. 5. Am. Gl gul f Mhlg ch vlu f l mc. Wl Hlh Ogz Gv. 2000. 27-31. JB, Mgkwjj S. 6. Smh Pmlh, mk ggu hw c h. Jk: Uv I P; 1988. hl. 47-49. 7. Suhm KS. Fmklg. E IV. Jk: Bg Fmklg FKUI. 1995. 43955,762-6. 8. Lu FC. Tkklg, g, l k. E II. Djmhk lh E Nugh. Jk: UI P. 1995.87-99. 9. A EJ, Muchl E, Sm AM. Tkklg umum g. Djmhk lh Wm YR, W MB. Jgjk: Gjh M Uvy P; 1986. 10.Guy AC. Flg mu mkm yk. E III. Djmhk lh Pu A. Jk: P Buku Kk EGC. 1997.742-9. 11.Gg WF. Buku j flg kk, E Bh I:. M. Djuh Wjjkuumh, P Buku Kk EGC, E 17. Jk.. 12.Pc Evly. Am flg uuk m. Jk: PT. Gm. 1983:259261 42 Jul Kfm I. Vl 2.1.2012 : 35-42 42 Jul Kfm I Vl 1.1.2012 : 35-42 Df Rujuk