LAMPIRAN 1 Gambar / foto sel mitosis pada jaringan karsinoma epidermoid (anak panah merah dengan perbesaran 400x) kontrol 76
LAMPIRAN 2 Analisa Statistik Perubahan Diameter Tumor Selisih diameter tumor Case Summaries N Mean Std. Deviation Median Minimum Maximum 3 1.1000.26458 1.0000.90 1.40 3.4333.25166.4000.20.70 3.4000.10000.4000.30.50 3 -.2667.20817 -.2000 -.50 -.10 12.4167.53739.4000 -.50 1.40 Case Summaries N Mean Std. Deviation Median Minimum Maximum N Mean Std. Deviation Median Minimum Maximum N Mean Std. Deviation Median Minimum Maximum N Mean Std. Deviation Median Minimum Maximum N Mean Std. Deviation Median Minimum Maximum Diameter Diameter tumor post tumor pre test test 3 3 1.3000 2.4000 1.47986 1.34536.6000 2.0000.30 1.30 3.00 3.90 3 3.5667 1.0000.55076.78102.3000.6000.20.50 1.20 1.90 3 3 1.1000 1.5000 1.47986 1.57162.4000.8000.10.40 2.80 3.30 3 3.9667.7000 1.15902.95394.4000.2000.20.10 2.30 1.80 12 12.9833 1.4000 1.08362 1.22771.4000 1.0500.10.10 3.00 3.90 77
Selisih diameter tumor a. Lilliefors Significance Correction Tests of Normality olmogorov-smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig..314 3..893 3.363.219 3..987 3.780.175 3. 1.000 3 1.000.292 3..923 3.463 Test of Homogeneity of Variances Selisih diameter tumor Levene Statistic df1 df2 Sig. 1.129 3 8.394 NPar Tests ruskal-wallis Test 78
Mann Whitney Test Mann-Whitney U Tumor diameter diference.000 b. Grouping Variable: Group 6.000-1.964.049.100 a Mann-Whitney U Tumor diameter diference.000 b. Grouping Variable: Group 6.000-1.964.049.100 a 79
Mann-Whitney U Tumor diameter diference.000 b. Grouping Variable: Group 6.000-1.964.049.100 a 80
Mann-Whitney U Tumor diameter diference.000 b. Grouping Variable: Group 6.000-1.964.049.100 a Mann-Whitney U Tumor diameter diference.000 b. Grouping Variable: Group 6.000-1.964.049.100 a 81
LAMPIRAN 3 Analisa Statistik Indek Mitosis Case Summaries N Mean Std. Deviation Median Minimum Maximum 3 3.2000.34641 3.4000 2.80 3.40 3 1.1333.11547 1.2000 1.00 1.20 3 1.0667.11547 1.0000 1.00 1.20 3.6667.11547.6000.60.80 12 1.5167 1.04606 1.1000.60 3.40 a. Lilliefors Significance Correction Tests of Normality olmogorov-smirnov a Shapiro-Wilk Statistic df Sig. Statistic df Sig..385 3..750 3.000.385 3..750 3.000.385 3..750 3.000.385 3..750 3.000 Test of Homogeneity of Variances Levene Statistic df1 df2 Sig. 5.333 3 8.026 NPar Tests ruskal-wallis Test Ranks N Mean Rank 3 11.00 3 7.00 3 6.00 3 2.00 12 82
Chi-Square df Asymp. Sig. Test Statistics a,b 9.804 a. ruskal Wallis Test 3.020 b. Grouping Variable: NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 5.00 15.00 3 2.00 6.00 6 NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 5.00 15.00 3 2.00 6.00 6 Mann-Whitney U.000 6.000-2.023.043 b. Grouping Variable:.100 a 83
NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 5.00 15.00 3 2.00 6.00 6 Mann-Whitney U.000 6.000-2.023 b. Grouping Variable:.043.100 a NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 4.00 12.00 3 3.00 9.00 6 84
Mann-Whitney U 3.000 9.000 -.745 b. Grouping Variable:.456.700 a NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 5.00 15.00 3 2.00 6.00 6 Mann-Whitney U.000 6.000-2.023.043 b. Grouping Variable:.100 a 85
NPar Tests Mann-Whitney Test Ranks N Mean Rank Sum of Ranks 3 5.00 15.00 3 2.00 6.00 6 Mann-Whitney U.000 6.000-2.023.043 b. Grouping Variable:.100 a 86
LAMPIRAN 4 Uji orelasi Selisih Diameter Tumor dan Indek Mitosis Explore Case Summaries N Mean Std. Deviation Median Minimum Maximum Selisih diameter tumor 12 12.4167 1.5167.53739 1.04606.4000 1.1000 -.50.60 1.40 3.40 Selisih diameter tumor Tests of Normality olmogorov-smirnov a *. This is a lower bound of the true significance. a. Lilliefors Significance Correction Shapiro-Wilk Statistic df Sig. Statistic df Sig..105 12.200*.988 12.999.369 12.000.742 12.002 Nonparametric Correlations Correlations Spearman's rho Selisih diameter tumor Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) **. Correlation is significant at the 0.01 level (2-tailed). N Selisih diameter tumor 1.000.813**..001 12 12.813** 1.000.001. 12 12 87
LAMPIRAN 5 Patologi Anatomi Sampel, Ukuran Diameter Tumor Pre dan Post Perlakuan, Indek Mitosis Post Perlakuan SCORING INDEX MITOSIS DALAM 5 LAPANG PANDANG BESAR HASIL PATOLOGI ANATOMI ELOMPO I II III IV V Mean ontrol A 4 3 3 5 2 3.4 SQUAMOUS CELL CA WELL DIFFERENTIATED B 2 3 4 3 2 2.8 SQUAMOUS CELL CA Insitu C 4 3 2 3 5 3.4 SQUAMOUS CELL CA Insitu mean 3.2 A 1 2 1 1 1 1.2 ERATOACANTOMA DENGAN SQUAMOUS CELL CA MIROINVASIF B 0 1 2 1 1 1 PAPILOMA CELL SQUAMOUS DENGAN FOUS CA C 3 1 1 1 0 1.2 SQUAMOUS CELL CA Insitu Mean 3.4 A 1 1 1 0 2 1 SQUAMOUS CELL CA WELL DIFF DENGAN NEROSIS LUAS B 2 2 0 1 1 1.2 SQUAMOUS CELL CA WELL DIFFERENTIATED C 1 0 2 2 0 1 SQUAMOUS CELL CA WELL DIFFERENTIATED mean 1.06 A 0 1 1 2 0 0.8 SQUAMOUS CELL CA WELL DIFFERENTIATED B 1 0 0 1 1 0.6 SQUAMOUS CELL CA Insitu C 1 1 0 1 0 0.6 SQUAMOUS CELL CA INSITU + MIROINVASIF mean 0.6 88
Data Ukuran Diameter Tumor Pre dan Post Perlakuan ontrol Diameter tumor pre test (cm) Diameter tumor post test (cm) Selisih diameter tumor (cm) A 3 3,9 0,9 B 0,6 2 1,4 C 0,3 1,3 1 Mean 1,1 A 1,2 1,9 0,7 B 0,2 0,6 0,4 C 0,3 0,5 0,2 Mean 0,43 A 2,8 3,3 0,5 B 0,1 0,4 0,3 C 0,4 0,8 0,4 Mean 0,4 A 2,3 1,8-0,5 B 0,4 0,2-0,2 C 0,2 0,1-0,1 Mean -0,26 eterangan : : ontrol : Phaleria macrocarpa 0,0715 mg (0,36 ml/hari). : sitostatika Paclitaxel 175 mg/m 2 dan cisplatin 50 mg/m 2 A B C : sitostatika Paclitaxel 175 mg/m 2 dan cisplatin 50 mg/m 2 dan dikombinasikan dengan Phaleria macrocarpa 0,0715 mg (0,36 ml/hari) : tanda asam pikrat pada mencit di kepala : tanda asam pikrat pada mencit di kaki depan : tanda asam pikrat pada mencit di ekor 89
LAMPIRAN 6 Foto Mencit yang Diinduksi Tumor, Perlakuan, dan Pengukuran Tumor Gambar. Mencit yang diinduksi karsinoma epidermoid Gambar. Pemberian Phaleria macrocarpa via sonde Gambar. Penyuntikan sitostatika Gambar. Pengukuran diameter tumor menggunakan caliper 90
LAMPIRAN 7 Foto Pemeliharaan Mencit 91
LAMPIRAN 8 Foto Pengolahan Ekstrak Phaleria macrocarpa 92
LAMPIRAN 9 93
LAMPIRAN 10 94