LAMPIRA 1. Bagan pembuatan sediaan krim Fase minyak Fase air - asam stearat - ipagin - setil alkoho - atrium edetat - gliseril monostearat - propilen glikol - Vaselin - trietanolamin - BHT - aquadest - dimasukkan ke dalam cawan penguap - dilebur di atas penangas air pada suhu 70 C - dilarutkan dalam air panas yg telah ditakar pada suhu 70 C Fase minyak + Fase air Dasar Krim - digerus konstan di dalam lumpang panas - ditambahkan 3 tetes pewangi Sari tomat - ditimbang masing-masing konsentrasi - dimasukkan bahan dasar krim ke dalam lumpang - ditambahkan sari tomat yang telah ditimbang sedikit demi sedikit hingga homogen Krim sari tomat 41
Lampiran 2. Hasil identifikasi tumbuhan 42
Lampiran 3. Gambar buah tomat, tomat setelah di potong, tomat di juice dan sari tomat yang telah di freeze drying Buah tomat Tomat setelah dipotong kecil - kecil 43
Lampiran 3. (Lanjutan) Tomat di juice Sari tomat yang telah di freeze drying 44
Lampiran 4. Gambar alat-alat penelitian A B Keterangan: A: Juicer yang berisi sampel (Miyako), B: Skin analyzer (Aramo), C: Moisturizer checker (Aramo), D: ph meter (Hanna Instrumen). C 45
Lampiran 5. Gambar sediaan setelah dimasukkan kedalam wadah dan gambar sediaan setelah penyimpanan hari ke 90 a. Gambar sediaan setelah dimasukkan kedalam wadah Keterangan : A : Blanko (dasar krim tanpa sampel). B : krim sari tomat 5% C : krim sari tomat 7,5% D : krim sari tomat 10% E : krim sari tomat 12% 46
Lampiran 5. (Lanjutan) b. Gambar sediaan setelah penyimpanan hari ke - 90 Keterangan : A : Blanko (dasar krim tanpa sampel). B : krim sari tomat 5% C : krim sari tomat 7,5% D : krim sari tomat 10% E : krim sari tomat 12% 47
Lampiran 6. Gambar hasil uji homogenitas dan tipe emulsi a. Uji homogenitas FA FB FC FD FE FF b. Tipe emulsi FA FB FC FD FE FF Keterangan : A : Blanko (dasar krim tanpa sampel). B : krim sari tomat 5% C : krim sari tomat 7,5% D : krim sari tomat 10% E : krim sari tomat 12% 48
Lampiran 7. Salah satu contoh hasil uji efektivitas anti-aging pada sukarelawan a.. Hasil pengukuran kadar air (Moisture) - Kondisi awal - Pemulihan minggu pertama (Minggu1) - Pemulihan minggu kedua (Minggu 2) - Pemulihan minggu ketiga (Minggu 3) - Pemulihan minggu ke empat (Minggu 4) 49
Lampiran 7. (Lanjutan) a. Hasil pengukuran kehalusan dan besar pori (Evenness/pore) - Kondisi awal - Pemulihan minggu pertama (Minggu1) 50
Lampiran 7. (Lanjutan) - Pemulihan minggu kedua (Minggu 2) - Pemulihan minggu ketiga (Minggu 3) 51
Lampiran 7. (Lanjutan) - Pemulihan minggu ke empat (Minggu 4) 52
Lampiran 7. (Lanjutan) b. Hasil pengukuran banyak noda (spot) - Kondisi awal - Pemulihan minggu pertama (Minggu1) 53
Lampiran 7. (Lanjutan) - Pemulihan minggu pertama (Minggu2) - Pemulihan minggu pertama (Minggu3) 54
Lampiran 7. (Lanjutan) - Pemulihan minggu pertama (Minggu4) 55
Lampiran 8. Hasil variansi (AAVA) dan Tukey untuk pemulihan kulit sukarelawan selama 4 minggu a. Kadar air (Moisture) AOVA Sum of Squares df Mean Square F Sig. minggu0 Between Groups 2.000 5.400.400.840 Within Groups 12.000 12 1.000 Total 14.000 17 minggu1 Between Groups 12.944 5 2.589 1.664.217 Within Groups 18.667 12 1.556 Total 31.611 17 minggu2 Between Groups 42.944 5 8.589 8.137.001 Within Groups 12.667 12 1.056 Total 55.611 17 minggu3 Between Groups 57.778 5 11.556 13.867.000 Within Groups 10.000 12.833 Total 67.778 17 minggu4 Between Groups 125.611 5 25.122 26.600.000 Within Groups 11.333 12.944 Total 136.944 17 56
minggu0 TukeyHSD a Subset for alpha = 0.05 1 Blanko 3 28.00 KST 5% 3 27.67 KST 7,5% 3 28.00 KST 10% 3 27.67 KST 12% 3 28.67 Olay 3 28.00 Sig..817 Means for groups in homogeneous subsets are displayed. minggu1 TukeyHSD a Subset for alpha = 0.05 1 Blanko 3 28.00 KST 5% 3 28.33 KST 7,5% 3 29.33 KST 10% 3 29.67 KST 12% 3 30.00 OLAY 3 30.33 Sig..269 Means for groups in homogeneous subsets are displayed. 57
minggu2 TukeyHSD a Subset for alpha = 0.05 1 2 3 Blanko 3 28.00 KST 5% 3 29.33 29.33 KST 7,5% 3 31.33 31.33 KST 10% 3 31.33 31.33 KST 12% 3 32.00 32.00 OLAY 3 32.33 Sig..620.067.833 Means for groups in homogeneous subsets are displayed. TukeyHSD a minggu3 Subset for alpha = 0.05 1 2 3 Blanko 3 29.00 KST 5% 3 30.00 30.00 KST 7,5% 3 32.33 32.33 KST 10% 3 32.67 KST 12% 3 33.33 OLAY 3 34.00 Sig..758.073.290 Means for groups in homogeneous subsets are displayed. 58
minggu4 TukeyHSD a Subset for alpha = 0.05 1 2 3 Blanko 3 29.33 KST 5% 3 30.00 KST 7,5% 3 33.33 KST 10% 3 33.67 KST 12% 3 35.33 35.33 OLAY 3 36.67 Sig..954.192.567 Means for groups in homogeneous subsets are displayed. 59
Lampiran 8. (Lanjutan) b. Kehalusan (Evenness) AOVA Sum of Squares df Mean Square F Sig. minggu0 Between Groups 4.667 5.933 1.200.366 Within Groups 9.333 12.778 Total 14.000 17 minggu1 Between Groups 9.333 5 1.867 1.768.194 Within Groups 12.667 12 1.056 Total 22.000 17 minggu2 Between Groups 37.111 5 7.422 8.907.001 Within Groups 10.000 12.833 Total 47.111 17 minggu3 Between Groups 78.278 5 15.656 10.437.000 Within Groups 18.000 12 1.500 Total 96.278 17 minggu4 Between Groups 98.278 5 19.656 27.215.000 Within Groups 8.667 12.722 Total 106.944 17 60
minggu0 TukeyHSD a Subset for alpha = 0.05 1 Olay 3 35.67 KST 12% 3 34.67 KST 10% 3 35.67 KST 7,5% 3 35.67 KST 5% 3 36.33 Blanko 3 36.00 Sig..260 Means for groups in homogeneous subsets are displayed. minggu1 TukeyHSD a Subset for alpha = 0.05 1 OLAY 3 34.00 KST 12% 3 34.33 KST 10% 3 34.67 KST 7,5% 3 35.33 Blanko 3 35.67 KST 5% 3 36.00 Sig..235 Means for groups in homogeneous subsets are displayed. 61
minggu2 TukeyHSD a Subset for alpha = 0.05 1 2 3 OLAY 3 32.00 KST 12% 3 32.33 32.33 KST 10% 3 33.00 33.00 KST 5% 3 34.67 34.67 KST 7,5% 3 34.67 34.67 Blanko 3 36.00 Sig..758.073.506 Means for groups in homogeneous subsets are displayed. TukeyHSD a minggu3 Subset for alpha = 0.05 1 2 KST 12% 3 30.00 KST 10% 3 31.00 OLAY 3 31.00 KST 7,5% 3 33.33 33.33 KST 5% 3 34.67 Blanko 3 35.67 Sig..052.253 Means for groups in homogeneous subsets are displayed. 62
minggu4 TukeyHSD a Subset for alpha = 0.05 1 2 3 4 OLAY 3 28.00 KST 12% 3 29.00 29.00 KST 10% 3 30.00 30.00 KST 7,5% 3 31.00 31.00 KST 5% 3 32.67 Blanko 3 35.00 Sig..110.110.229 1.000 Means for groups in homogeneous subsets are displayed. 63
Lampiran 8. (Lanjutan) c. pori (pore) AOVA Sum of Squares df Mean Square F Sig. minggu0 Between Groups 47.611 5 9.522 1.843.179 Within Groups 62.000 12 5.167 Total 109.611 17 minggu1 Between Groups 104.500 5 20.900 3.215.045 Within Groups 78.000 12 6.500 Total 182.500 17 minggu2 Between Groups 277.111 5 55.422 9.152.001 Within Groups 72.667 12 6.056 Total 349.778 17 minggu3 Between Groups 445.778 5 89.156 15.284.000 Within Groups 70.000 12 5.833 Total 515.778 17 minggu4 Between Groups 625.833 5 125.167 15.538.000 Within Groups 96.667 12 8.056 Total 722.500 17 64
minggu0 Tukey HSD a Subset for alpha = 0.05 1 Olay 3 31.33 KST 12% 3 32.33 KST 10% 3 32.33 KST 7,5% 3 32.67 KST 5% 3 32.33 Blanko 3 35.33 Sig..253 Means for groups in homogeneous subsets are displayed. Tukey HSD a minggu1 Subset for alpha = 0.05 1 2 OLAY 3 28.33 KST 12% 3 32.00 32.00 KST 10% 3 31.00 31.00 KST 7,5% 3 31.33 31.33 KST 5% 3 35.00 35.00 Blanko 3 35.33 Sig..065.357 Means for groups in homogeneous subsets are displayed. 65
minggu2 Tukey HSD a Subset foralpha = 0.05 1 OLAY 3 23.00 KST 12% 3 28.67 28.67 KST 10% 3 29.00 29.00 KST 7,5% 3 29.67 29.67 KST 5% 3 35.33 Blanko 3 35.33 Sig..054.093 Means for groups in homogeneous subsets are displayed. Tukey HSD a minggu3 Subset for alpha = 0.05 1 2 3 4 OLAY 3 18.33 KST 12% 3 25.00 KST 10% 3 26.67 26.67 KST 7,5% 3 27.00 27.00 KST 5% 3 32.00 32.00 Blanko 3 33.67 Sig. 1.000.904.145.953 Means for groups in homogeneous subsets are displayed. 66
minggu4 Tukey HSD a Subset for alpha = 0.05 1 2 3 4 OLAY 3 15.67 KST 12% 3 22.33 22.33 KST 10% 3 24.00 24.00 KST 7,5% 3 26.00 26.00 26.00 KST 5% 3 31.67 31.67 Blanko 3 33.33 Sig..111.624.054.069 Means for groups in homogeneous subsets are displayed. 67
Lampiran 8. (Lanjutan) d. oda (spot) AOVA Sum of Squares df Mean Square F Sig. minggu0 Between Groups 10.500 5 2.100.900.512 Within Groups 28.000 12 2.333 Total 38.500 17 minggu1 Between Groups 37.833 5 7.567 2.619.080 Within Groups 34.667 12 2.889 Total 72.500 17 minggu2 Between Groups 81.333 5 16.267 5.976.005 Within Groups 32.667 12 2.722 Total 114.000 17 minggu3 Between Groups 203.111 5 40.622 12.607.000 Within Groups 38.667 12 3.222 Total 241.778 17 minggu4 Between Groups 379.167 5 75.833 16.446.000 Within Groups 55.333 12 4.611 Total 434.500 17 68
minggu0 TukeyHSD a Subset for alpha = 0.05 1 OLAY 3 29.67 KST 7,5% 3 31.00 KST 10% 3 31.00 KST 5% 3 31.67 KST 12% 3 31.67 Blanko 3 32.00 Sig..462 Means for groups in homogeneous subsets are displayed. minggu1 TukeyHSD a Subset for alpha = 0.05 1 OLAY 3 28.33 KST 12% 3 28.33 KST 10% 3 30.00 KST 7,5% 3 30.67 KST 5% 3 31.67 Blanko 3 32.00 Sig..160 Means for groups in homogeneous subsets are displayed. 69
minggu2 TukeyHSD a Subset for alpha = 0.05 1 2 KST 12% 3 26.33 OLAY 3 26.67 KST 10% 3 28.67 28.67 KST 7,5% 3 29.00 29.00 KST 5% 3 31.33 Blanko 3 32.00 Sig..406.206 Means for groups in homogeneous subsets are displayed. TukeyHSD a minggu3 Subset for alpha = 0.05 1 2 3 4 OLAY 3 22.33 KST 12% 3 24.33 24.33 KST 10% 3 25.67 25.67 25.67 KST 7,5% 3 28.00 28.00 28.00 KST 5% 3 30.33 30.33 Blanko 3 32.00 Sig..275.198.067.140 Means for groups in homogeneous subsets are displayed. 70
minggu4 TukeyHSD a Subset for alpha = 0.05 1 2 3 OLAY 3 19.33 KST 12% 3 21.33 KST 10% 3 23.00 23.00 KST 7,5% 3 27.33 27.33 KST 5% 3 30.33 Blanko 3 31.67 Sig..352.207.207 Means for groups in homogeneous subsets are displayed. 71
SURAT PERYATAA PERSETUJUA IKUT SERTA DALAM PEELITIA ama lengkap Usia Jenis kelamin Alamat :.. :. :. :. Bersedia menjadi sukarelawan untuk test anti-aging?. Telah mendapat penjelasan secukupnya bahwa tangan saya akan digunakan sebagai daerah yang akan dianalisis. Setelah mendapat penjelasan secukupnya tentang manfaat penelitian ini maka saya menyatakan SETUJU untuk ikut serta dalam penelitian DARA YUITA dengan judul FORMULASI SEDIAA KRIM SARI TOMAT (Solanum lycopersicum L.) DA UJI EFEK ATI-AGIG sebagai usaha untuk mengetahui apakah sediaan krim yang dihasilkan mampu memberikan efek anti penuaan dini. Saya menyatakan sukarela dan bersedia untuk mengikuti prosedur penelitian yang telah ditetapkan. Persetujuan ini saya buat dengan penuh kesadaran dan tanpa paksaan dari pihak manapun. Demikian surat pernyataan ini dibuat untuk dapat dipergunakan sebagaimana mestinya. Peneliti, Medan, September 2015 Dara Yunita IM 101501008 IM 72