UNIVERSITAS AIRLANGGA DIREKTORAT PENDIDIKAN Tim Pengembangan Jurnal Universitas Airlangga Kampus C Mulyorejo Surabaya

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2 EDITORIAL BOARD Dewan Redaksi MAJALAH ILMU FAAL INDONESIA The Indonesian Journal of Physiology VOLUME 10 NOMOR 2, SEPTEMBER 2013 Majalah Ilmu Faal Indonesia memuat tulisan ilmiah yang terkait dengan bidang fisiologi. Terbit setiap 4 bulan, berdasarkan SK Ketua Umum Pengurus Pusat Ikatan Ahli Ilmu Faal Indonesia No. 001/SK/IAIFI/IX/2000, tanggal 14 September 2000 Susunan Dewan Redaksi Ketua Penyunting Purwo Sri Rejeki Sekretaris Sundari Indah Wiyasihati Bendahara Ratna Damayanti Iklan dan Langganan Yuliati Penyunting Pelaksana Lilik Herawati Raden Argarini Aqsa Sjuhada Irfiansyah Irwadi Penyunting Teknik Kuncoro Puguh Santoso Tata Usaha Muhammad Taufik Kurniadi Alamat : Departemen Faal Fakultas Kedokteran Universitas Airlangga Jl. Mayjen. Prof. Dr. Moestopo 47 Surabaya Telp: (031) Fax: (031) workshop.mifi@yahoo.com Rekening : Ratna Damayanti, drh., M.Kes Bank NIAGA IBC Dharmahusada Surabaya No MAJALAH ILMU FAAL INDONESIA diterbitkan oleh Ikatan Ahli Ilmu Faal Indonesia (IAIFI) Harga berlangganan : Rp ,00 per nomor MAJALAH ILMU FAAL INDONESIA The Indonesian Journal of Physiology VOLUME 10 NOMOR 2, SEPTEMBER 2013 Majalah Ilmu Faal Indonesia memuat tulisan ilmiah yang terkait dengan bidang fisiologi. Terbit setiap 4 bulan, berdasarkan SK Ketua Umum Pengurus Pusat Ikatan Ahli Ilmu Faal Indonesia No. 001/SK/IAIFI/IX/2000, tanggal 14 September 2000 Susunan Dewan Redaksi Ketua Penyunting Purwo Sri Rejeki Sekretaris Sundari Indah Wiyasihati Bendahara Ratna Damayanti Iklan dan Langganan Yuliati Penyunting Pelaksana Lilik Herawati Raden Argarini Aqsa Sjuhada Irfiansyah Irwadi Penyunting Teknik Kuncoro Puguh Santoso Tata Usaha Muhammad Taufik Kurniadi Alamat : Departemen Faal Fakultas Kedokteran Universitas Airlangga Jl. Mayjen. Prof. Dr. Moestopo 47 Surabaya Telp: (031) Fax: (031) workshop.mifi@yahoo.com Rekening : Ratna Damayanti, drh., M.Kes Bank NIAGA IBC Dharmahusada Surabaya No MAJALAH ILMU FAAL INDONESIA diterbitkan oleh Ikatan Ahli Ilmu Faal Indonesia (IAIFI) Harga berlangganan : Rp ,00 per nomor page 2 / 5

3 Table of Contents No Title Page 1 Red Spinach (Amaranthus tricolor) Juice Administration to Mother Mice Exposed by Lead Acetate in Gestation Periode Improves Learning Ability and Memory of Post Weaning Mice (Mus musculus) Offspring 1-5 page 3 / 5

4 Vol No. 1 / TOC : 1, and page : 1-5 Red Spinach (Amaranthus tricolor) Juice Administration to Mother Mice Exposed by Lead Acetate in Gestation Periode Improves Learning Ability and Memory of Post Weaning Mice (Mus musculus) Offspring Pemberian Jus Bayam Merah (Amaranthus tricolor) pada Induk Mencit Bunting yang Terpapar Timbal Asetat Meningkatkan Kemampuan Belajar dan Memori Anak Mencit (Mus musculus) Pascasapih Author : Made Puri Pratiwi madepury@gmail.com Noer Halimatus Syakdiyah Etha Dini Widiasi Mayang Rizki Anggraeni Intan Anggun Pratiwi Viskasari Pintoko Kalanjati Fakultas Kedokteran Raden Argarini3 Fakultas Kedokteran Abstract Lead acetate is chemical substance which can give negative effects to brain development. The effect is decreasing of learning ability and memory. The aim of this research was to know the effect of red spinach (Amaranthus tricolor) juice to learning ability and memory of post weaning mice offspring from mother mice exposing by lead acetate during gestation period. Thirty three post weaning mice offspring were tested for learning ability and memory by using Morris Water Maze one week after weaning day. Offspring was gained from mother mice that was given three different interventions during gestation period for 21 days. Group K was control group with placebo. Group M1 was given lead acetate 1.16 mg/10gbw/day and CMC 0.5%. Group M2 was given lead acetate 1.16 mg/10gbw/day and red spinach juice mg/10 gbw/day. Mice offspring was weaned three weeks after birth day. Mice offspring was given memory consolidation trial four times a day for four days to obtain latency time and memory test to obtain frequency of passing the platform. Latency time of group M2 in the first day 10.98±4.47, the forth day 13.35±3.1 and frequency passing the platform 16.7±4.69 is significantly increasing compared with group K (6.15±3.8; 9.6±3.64; 8.5±2.07) and M1 (7.4±2.77; 12.8±3.29; 10.4±3.53) with significant value in order p=0.021, p=0.04 and p=0.000 (α=0.05). Group K and M1 show insignificant result of latency time and frequency passing the platform. Our research suggested that administration of red spinach juice to mother mice exposed by lead acetate in gestation period can improve learning ability and memory of mice offspring and lead exposure in low dose 1.16 mg/10 gbw/day does not decrease learning ability and memory of mice offspring. Keyword : red, spinach, juice, lead, acetate, learning, ability, memory, Daftar Pustaka : 1. NHMRC, (2009). Blood lead levels. Australia : Lead exposure and health effects page 4 / 5

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